3D Structure and Protein Interaction Analysis

Genome sequencing projects are producing linear amino acid sequences, but full understanding of the biological role of these proteins requires knowledge of their structure and function. Although experimental structure determination methods are providing high-resolution structure information about a subset of the proteins, computational structure prediction methods provides valuable information for the large fraction of sequences whose structures cannot be determined experimentally. Three-dimensional (3D) protein structure is an important source of information to better understand the function of a protein, its interactions with other compounds (ligands, proteins, DNA) and to understand phenotypic effects of mutations, better understanding of processes such as metabolic control, signal transduction, gene regulation and for drug discovery.

Services Offered

Javik Data offers protein 3D structure determination using de novo folding and homology modeling. We also performprotein-protein and protein-ligand interaction analysisusing computational docking. We use pharmacophore modeling to generate and use 3D information to search for novel active compounds particularly when no receptor geometry is available.

Mail us at:

info@jaivikdata.com

Molecular Dynamics Studies

A fundamental principle of how biological macromolecules work requires knowledge of structure and dynamics. Molecular dynamics simulations provide powerful tools for the exploration of the conformational energy landscape accessible to these molecules, and the rapid increase in computational power coupled with improvements in methodology for the application of simulation to structural biology. Molecular dynamics simulations are useful in the study of motion on the picosecond to microsecond timescale. Specifically for protein dynamics, it has been a useful technique for the characterization of protein folding kinetics, protein conformational changes, protein structure refinement and protein structure prediction.

Services Offered

At Jaivik Data we offer, end to end molecular dynamic analysis service to our clients including dramatically increased speed of simulations to improve results and new models to allow molecular dynamic analysis for extremely big proteins.

Mail us at:

info@jaivikdata.com

For More Information011-27942380info@jaivikdata.com Partner Programs